Viral DNA polymerase scanning and the gymnastics of Sendai virus RNA synthesis.
نویسندگان
چکیده
mRNA synthesis from nonsegmented negative-strand RNA virus (NNV) genomes is unique in tht the genome RNA is embedded in an N protein assembly (the nucleocapsid) and the viral RNA polymerase does not dissociate from the template after release of each mRNA, but rather scans the genome RNA for the next gene-start site. A revised model for NNV RNA synthesis is presented, in which RNA polymerase scanning plays a prominent role. Polymerase scanning of the template is known to occur as the viral transcriptase negotiates gene junctions without falling off the template.
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عنوان ژورنال:
- Virology
دوره 318 2 شماره
صفحات -
تاریخ انتشار 2004